|Trade names||Epidiolex, Epidyolex|
|Other names||CBD, cannabidiolum, (−)-cannabidiol|
|Inhalation (smoking, vaping), buccal (aerosol spray),oral (solution)|
|Bioavailability||• Oral: 13–19%|
• Inhaled: 31% (11–45%)
|Elimination half-life||18–32 hours|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||314.469 g·mol−1|
|3D model (JSmol)|
|Melting point||66 °C (151 °F)|
|Solubility in water||insoluble|
Cannabidiol (CBD) is a phytocannabinoid discovered in 1940. It is one of 113 identified cannabinoids in cannabis plants, along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. As of 2019, clinical research on CBD included studies related to anxiety, cognition, movement disorders, and pain, but there is insufficient high-quality evidence that cannabidiol is effective for these conditions.
Cannabidiol can be taken internally in multiple ways, including by inhaling cannabis smoke or vapor, by mouth, and as an aerosol spray into the cheek. It may be supplied as CBD oil containing only CBD as the active ingredient (excluding tetrahydrocannabinol [THC] or terpenes), CBD-dominant hemp extract oil, capsules, dried cannabis, or prescription liquid solution. CBD does not have the same psychoactivity as THC, and may change the effects of THC on the body if both are present. As of 2018[update], the mechanism of action for its biological effects has not been determined.
In the United States, the cannabidiol drug Epidiolex was approved by the Food and Drug Administration in 2018 for the treatment of two epilepsy disorders. Since cannabis is a Schedule I controlled substance in the United States, other CBD formulations remain illegal under federal law to prescribe for medical use or to use as an ingredient in dietary supplements or other foods.